Pulmonary delivery of favipiravir inhalation solution for COVID-19 treatment: in vitro characterization, stability, in vitro cytotoxicity, and antiviral activity using real time cell analysisArticle Published on 2022-12-012022-11-15 Journal: Drug Delivery [Category] COVID19(2023년), SARS, 치료제, [키워드] addition administration Analysis Antiviral antiviral activity Calu-3 Cell characterized Concentration COVID-19 cytotoxicity Favipiravir in vitro indicated Influenza virus Inhaled inhaled formulation inhibitor investigated lung lung epithelial cell lung tissue Lungs media Patient patients with COVID-19 PBS phosphate buffer profile pulmonary RdRP real time required respiratory. RNA-dependent RNA polymerase SARS-CoV-2 stability target Toxicity treat Treatment VERO-E6 viability were infected [DOI] 10.1080/10717544.2022.2118398 PMC 바로가기
Effect of oral antiseptics in reducing SARS-CoV-2 infectivity: evidence from a randomized double-blind clinical trialRandomized Controlled Trial Published on 2022-12-012022-10-05 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 임상, [키워드] antiseptic mouthwashe cell cultures cetylpyridinium chloride clinical trial COVID-19 COVID-19 patients Culture double-blind Effect evaluated Evidence in vitro in vivo indicated Infectivity Mouthwash mouthwashe mouthwashes not affected Placebo placebo-controlled clinical trial quantitative PCR Randomized reduce reduced reducing Saliva Saliva. salivary SARS-CoV-2 shown significantly tested viability viral infectivity Viral load Viral transmission virucidal [DOI] 10.1080/22221751.2022.2098059 PMC 바로가기 [Article Type] Randomized Controlled Trial
Understanding and combating COVID-19 using the biology and chemistry of SARS-CoV-2Article Published on 2022-11-012022-11-15 Journal: Bioprocess and biosystems engineering [Category] SARS, 치료기술, [키워드] ACE acute respiratory syndrome angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 (ACE2) Asymptomatic binding caused combating contributed coronavirus coronavirus disease COVID-19 enzyme high affinity host receptor hydrophobic Infection Interaction lead to fatality Like molnupiravir Mutation Nanotechnology omicron pandemic pathogenic viruses PAXLOVID™ provide quercetin Remdesivir responsible SARS-CoV-2 spike glycoprotein suggested Transmissibility understanding vaccine. Vaccines viability virus [DOI] 10.1007/s00449-022-02788-8 PMC 바로가기
SARS-CoV-2 air and surface contamination in residential settingsArticle Published on 2022-10-272022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] absence Contamination COVID-19 patient determine evaluate fraction highest investigated Isolation methodology mild symptoms occur occurred Occurrence Particles performed persistence positive SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2-infected patient selected surface symptom onset the patient Transmission viability virus virus particle [DOI] 10.1038/s41598-022-22679-y PMC 바로가기
Murine Hepatitis Virus, a Biosafety Level 2 Model for SARS-CoV-2, Can Remain Viable on Meat and Meat Packaging Materials for at Least 48 HoursArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 치료기술, [키워드] biosafety Biosafety Level 2 bottleneck BSL2 Can condition conditions contribute coronavirus Coronaviruses COVID-19 case creating detectable determine Evidence facilitate Factor FIVE highest hour hpi hygiene inoculated involved material meat MHV Model murine hepatitis virus notable outbreak packaging material. Particles persistence physical physical distancing plant provide reduction reduction in reservoir resulting SARS-CoV-2 Spread spread of COVID-19 steadily decreased Styrofoam survival tested unpaired t test viability Viable viral infectivity virus [DOI] 10.1128/spectrum.01862-22 PMC 바로가기
Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replicationArticle Published on 2022-10-142022-11-16 Journal: Life Science Alliance [Category] COVID19(2023년), SARS, 변종, [키워드] Analysis association Calu-3 cell cellular Comorbidity components COVID-19 demonstrated effective eQTL examined EXOSC2 expression form Genome-wide association study higher risk host protein host-virus interactions human RNA identify impede increased expression interact Interaction loci New nonsense mutation polymerase PROTECT Protein protein expression reduced risk loci RNA RNA polymerase Safe SARS-CoV-2 proteins SARS-CoV-2 replication SARS-CoV-2 viral infection the SARS-CoV-2 therapeutic target Treatment valuable resource viability Viral RNA with COVID-19 [DOI] 10.26508/lsa.202201449 PMC 바로가기
Toxicity and virucidal activity of a neon-driven micro plasma jet on eukaryotic cells and a coronavirusArticle Published on 2022-10-012022-11-15 Journal: Free radical biology & medicine [Category] COVID19(2023년), SARS, 치료제, [키워드] abrogated airway antioxidant antiviral activity chronic wound clinics Cold Cold physical plasma complex Contact coronavirus cytotoxic effect cytotoxicity Direct Effect Effects eukaryotic cell fibroblast Gas plasma technology Hepatitis human cell line human cells human coronaviruses identify inactivation increasingly infections mechanism metabolic activity MHV murine murine hepatitis virus number of infected oxygen pandemic Patient physical plasma plethora reactive oxygen reactive oxygen species reduced responsible ROS ROS production Safe substrate the SARS-CoV-2 therapeutic purposes tissue Toxicity treat Treatment unique viability virucidal virus inactivation Virus inactivation. [DOI] 10.1016/j.freeradbiomed.2022.08.026 PMC 바로가기
Impact of the COVID-19 pandemic on the South African tobacco and alcohol industries: Experiences from British American Tobacco and Distell Group LimitedResearch article Published on 2022-10-012022-10-05 Journal: Physics and Chemistry of the Earth, Parts A/B/C [Category] 진단, [키워드] African alcohol British American Tobacco COVID-19 COVID-19 pandemic determine DGH disaster Distell group holding Effect experience Google Finance group Impact Limited Local lockdown long-lasting mitigate Policy promote reduced Share price South South Africa state stock Support Test utilised viability widespread [DOI] 10.1016/j.pce.2022.103186 [Article Type] Research article
Preclinical safety evaluation and tracing of human mesenchymal stromal cell spheroids following intravenous injection into cynomolgus monkeysResearch article Published on 2022-10-012022-10-05 Journal: Biomaterials [Category] Coronavirus, 비임상, [키워드] addressed administration ambient Blood blood vessel Cell death demonstrated dissociate Efficacy feasible Host hypoxic condition injection intravenous Intravenous injection less lung Mesenchymal stem cells mice Monkey MSC MSCs multiple sclerosis occurred Osteoarthritis physiological change Preclinical promote retention Safe Safety Single Cell small blood vessel small vessel Spheroid Stress stromal cell survival viability wound healing [DOI] 10.1016/j.biomaterials.2022.121759 [Article Type] Research article
SARS-CoV-2 infects adipose tissue in a fat depot- and viral lineage-dependent mannerArticle Published on 2022-09-292022-11-15 Journal: Nature Communications [Category] SARS, 변종, 진단, [키워드] ACE2 adipose Adiposity anatomical Cell cell death cells cellular response Disease progression Express expression fat fat cell infect Infection Lineage occur pro-inflammatory cytokines risk factor SARS-CoV-2 SARS-COV-2 infection severe COVID-19 susceptibility susceptible the SARS-CoV-2 tissue variant viability visceral [DOI] 10.1038/s41467-022-33218-8 PMC 바로가기